Effects of ozone and nitrogen dioxide on pulmonary function in healthy and in asthmatic adolescents
The aim of this project was to investigate whether well-characterized asthmatic adolescent subjects were more sensitive to the inhaled effects of oxidant pollutants than were well-characterized healthy adolescent subjects. Ten healthy and 10 asthmatic subjects inhaled via a mouth-piece 0.12 or 0.18 ppm of ozone (O/sub 3/) or nitrogen dioxide (NO/sub 2/) or clean air for 30 min at rest followed by 10 min during moderate exercise (32.5 L/min) on a treadmill. The following pulmonary functional values were measured before and after exposure: peak flow, total respiratory resistance (RT), maximal flow at 50 and 75% of expired VC, and FEV1. After exercise exposure to 0.18 ppm O3, statistically significant increases were seen in RT in asthmatic and healthy adolescent subjects. No consistent changes were seen in either group after NO/sub 2/ exposure. Also, no significant differences in response to oxidant pollutants between the 2 groups could be demonstrated. It was concluded that neither group was consistently sensitive to these pollutants.
- Research Organization:
- Univ. of Washington, Seattle
- OSTI ID:
- 5833612
- Journal Information:
- Am. Rev. Respir. Dis.; (United States), Vol. 136:5
- Country of Publication:
- United States
- Language:
- English
Similar Records
The effects of ozone and nitrogen dioxide on lung function in healthy and asthmatic adolescents
The effects of inhaled sulfuric acid on pulmonary function in adolescent asthmatics
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ASTHMA
PATHOGENESIS
LUNGS
DYNAMIC FUNCTION STUDIES
SENSITIVITY
NITROGEN DIOXIDE
TOXICITY
OZONE
ADOLESCENTS
AIR POLLUTION
DOSE-RESPONSE RELATIONSHIPS
EXERCISE
INHALATION
RESPIRATION
AGE GROUPS
BODY
CHALCOGENIDES
DISEASES
INTAKE
NITROGEN COMPOUNDS
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology