Sequential changes in the mechanical properties of viable articular cartilage stored in vitro
Journal Article
·
· J. Orth. Res.; (United States)
Viable articular cartilage from the medial femoral condyles of rabbits was stored in vitro in tissue culture medium with various additives and the same site of each specimen was mechanically tested sequentially throughout a 12-day storage period. Indentation testing was performed with instantaneous and sustained loads. Preservation of sustained-load carrying capacity was observed in the condyles stored with additives, indicating maintenance of an intact cartilage matrix. However, initial testing with small sustained loads (preload) showed changes not observed at higher load levels. The changes noted at small sustained initial loads may reflect alterations in cartilage surface structure and may be an early indicator of its mechanical integrity. Chondrocyte viability and proteoglycan content, as measured by /sup 35/S incorporation and hexosamine concentration, were unchanged in comparison to fresh articular cartilage.
- Research Organization:
- Univ. of Pennsylvania School of Medicine, Philadelphia
- OSTI ID:
- 5832899
- Journal Information:
- J. Orth. Res.; (United States), Journal Name: J. Orth. Res.; (United States) Vol. 2:1; ISSN JORED
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BONE JOINTS
CARBOHYDRATES
CARTILAGE
CONNECTIVE TISSUE
CULTURE MEDIA
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
FEMUR
HEXOSAMINES
HEXOSES
IN VITRO
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MECHANICAL PROPERTIES
MONOSACCHARIDES
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PRESERVATION
RABBITS
RADIOISOTOPES
SACCHARIDES
SKELETON
SULFUR 35
SULFUR ISOTOPES
TIME DEPENDENCE
TISSUE CULTURES
TISSUES
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BONE JOINTS
CARBOHYDRATES
CARTILAGE
CONNECTIVE TISSUE
CULTURE MEDIA
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
FEMUR
HEXOSAMINES
HEXOSES
IN VITRO
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MECHANICAL PROPERTIES
MONOSACCHARIDES
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PRESERVATION
RABBITS
RADIOISOTOPES
SACCHARIDES
SKELETON
SULFUR 35
SULFUR ISOTOPES
TIME DEPENDENCE
TISSUE CULTURES
TISSUES
TRACER TECHNIQUES
UPTAKE
VERTEBRATES