Behavior of lead and zinc in plasma, erythrocytes, and urine and ALAD in erythrocytes following intravenous infusion of CaEDTA in lead workers
To evaluate the effect of calcium disodium ethylenediamine tetraacetate (CaEDTA) on concentrations of lead and zinc in plasma, erythrocytes, whole blood, and urine, CaEDTA was administered by intravenous infusion for 1 hr to seven lead workers with blood lead concentrations of 46-67 ..mu..g/100 g (mean 54 ..mu..g/100 g). The plasma lead concentration (PPb) and the mobilization yield of lead in urine by CaEDTA were highest during the period between 1 and 2 hr after the infusion was started. In contrast, the lead concentration in erythrocytes (EPb) and in whole blood (BPb) remained unchanged during the 24 hr following infusion. Plasma zinc concentration (PZn) also fell rapidly following CaEDTA infusion; the decline was followed by a gradual rise in the zinc concentration in erythrocytes (EZn) without alteration in the zinc in whole blood. The mobilization yield of zinc in urine by CaEDTA (MZn) reached its highest level within 1 hr after the start of the infusion. Delta-aminolevulinic acid dehydratase (ALAD) activity in erythrocytes gradually increased for 5 hr following CaEDTA infusion. These observations suggest that (1) PPb concentration is a more sensitive indicator of the body burden of chelatable lead than is either BPb or EPb; (2) MZn is mobilized mostly from plasma during the first several hours following the start of CaEDTA infusion, and the fall in PZn concentration following infusion is compensated first by a rise in EZn concentration and then by an immediate redistribution of zinc in other organs to the blood; and (3) Pb-inhibited ALAD activity is reactivated by the increased EZn during and shortly after CaEDTA infusion.
- Research Organization:
- Medical College of Oita, Japan
- OSTI ID:
- 5829160
- Journal Information:
- Arch. Environ. Health; (United States), Vol. 39:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
EDTA
BIOLOGICAL EFFECTS
LEAD
TISSUE DISTRIBUTION
LYASES
ENZYME REACTIVATION
ZINC
BLOOD
BLOOD PLASMA
BODY BURDEN
CALCIUM COMPOUNDS
DECONTAMINATION
ERYTHROCYTES
EXPERIMENTAL DATA
PERSONNEL
REMOVAL
TIME DEPENDENCE
URINE
ALKALINE EARTH METAL COMPOUNDS
AMINO ACIDS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEANING
DATA
DISTRIBUTION
ELEMENTS
ENZYMES
INFORMATION
MATERIALS
METALS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
WASTES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)