Circadian manifestations of barbiturate habituation, addiction and withdrawal in the rat

Conference · Sun Dec 31 23:00:00 EST 1978

OSTI ID:5827468

Ehret, C. F.; Peraino, C.; Meinert, J. C.; Groh, K. R.

The present study uses circadian rhythm observations on rats to include diverse habituation and drug ingestion (phenobarbital) circumstances, including a comparison of the effect of pre-entrainment cycles of programmed feeding and illumination and subsequent conditions of exposure of duration sufficient to permit a steady-state in the appearance of circadian patterns derived from core-temperature telemetry and from automated food-consumption measurements. Finally, measurements were permitted to continue long enough after the drug was withdrawn from the diet to allow characterization of an abstinence syndrome, indicative of addiction.

• Research Organization: Argonne National Lab., IL (USA)
• Sponsoring Organization: USDOE
• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 5827468
• Report Number(s): CONF-790762--1
• Country of Publication: United States
• Language: English

Related Subjects

550100 -- Behavioral Biology
550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AZINES
BARBITURATES
BEHAVIOR
BIOLOGICAL EFFECTS
DAILY VARIATIONS
DIET
DISEASES
DRUGS
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
INGESTION
INTAKE
MAMMALS
MENTAL DISORDERS
NERVOUS SYSTEM DISEASES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PHENOBARBITAL
PHYSIOLOGY
PYRIMIDINES
RATS
RODENTS
VARIATIONS
VERTEBRATES