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Postirradiation squamous cell carcinoma in situ of the vagina: treatment by topical 20 percent 5-fluorouracil cream

Journal Article · · Am. J. Obstet. Gynecol.; (United States)
OSTI ID:5824695
; ; ; ;

Eight patients with squamous cell carcinoma in situ of the vagina were treated with monthly 5 day courses of 20% 5-fluorouracil cream applied to the vagina. Seven (87.5%) of the women had an initial complete response; however, three subsequently developed recurrence after the treatment was stopped. They were retreated, and two of these three patients achieved a subsequent complete response. The overall response to therapy was 75% (6/8) with the six women off therapy from 1.1 to 6.9 years. Total follow-up of all patients was 3.1 to 6.9 years with no patients having developed invasive carcinoma. Because of the high success rate with no associated serious sequelae, this is believed to be a satisfactory method of therapy for women with squamous cell carcinoma in situ of the vagina occurring after pelvic irradiation.

Research Organization:
Roswell Park Memorial Inst., Buffalo, NY
OSTI ID:
5824695
Journal Information:
Am. J. Obstet. Gynecol.; (United States), Journal Name: Am. J. Obstet. Gynecol.; (United States) Vol. 135:3; ISSN AJOGA
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOMAS
DATA
DATA FORMS
DELAYED RADIATION EFFECTS
DISEASES
DRUGS
EPITHELIUM
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
FEMALE GENITALS
FLUOROURACILS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INFORMATION
IRRADIATION
ISOLATED VALUES
LABELLED COMPOUNDS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PARTIAL BODY IRRADIATION
PELVIS
PYRIMIDINES
RADIATION EFFECTS
RADIOACTIVE MATERIALS
RADIOINDUCTION
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
SIDE EFFECTS
THERAPY
TISSUES
URACILS