Studies of pancreatic carcinogenesis in different animal models

Journal Article · Fri Jun 01 04:00:00 EDT 1984 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.2307/3429848· OSTI ID:5824550

Scarpelli, D G; Rao, M S; Reddy, J K

Pancreatic carcinomas can be induced in rats, guinea pigs, and hamsters by a variety of carcinogens. The types of neoplasms which arise vary with the species of rodent. In the rat, they consist exclusively of acinar cells, in the other species the lesions are adenocarcinomas resembling those derived from pancreatic ductules and ducts, those in hamster more so than in guinea pigs. Careful sequential studies in the guinea pig and hamster suggest that acinar cells together with ductular and duct cells are involved in the genesis of duct adenocarcinomas. In each rodent model, the acinar cell appears to be quite sensitive to continued exposure to carcinogen. In each instance, acini undergo modulation, and in the guinea pig and hamster, permanent metaplastic transformation to ductlike structures. Such cells assume an enhanced capacity for cell proliferation which persists following cessation of carcinogen treatment. Other studies suggest that adult pancreatic acinar cells possess a surprising degree of plasticity. Their involvement in the pathogenesis of neoplasms resembling pancreatic ducts is not unlike other carcinogenic sequences where extensive cell modulation and metaplasia precede and are an integral part of the neoplastic transformation. 55 references, 9 figures, 4 tables.

• Research Organization: Northwestern Univ. Medical School, Chicago, IL
• OSTI ID: 5824550
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 56; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AFRICA
ANIMAL CELLS
ANIMALS
BIOLOGICAL MODELS
BODY
CARCINOGENS
CARCINOMAS
CELL PROLIFERATION
DIGESTIVE SYSTEM
DISEASES
DOMESTIC ANIMALS
ENDOCRINE GLANDS
GLANDS
GUINEA
HAMSTERS
MAMMALS
NEOPLASMS
ORGANS
PANCREAS
PATHOGENESIS
RATS
RODENTS
SENSITIVITY
SPECIES DIVERSITY
SWINE
VERTEBRATES