Prognostic value of intravenous dipyridamole thallium scintigraphy after an acute myocardial ischemic event

Journal Article · Sat Jul 15 00:00:00 EDT 1989 · Am. J. Cardiol.; (United States)

DOI:https://doi.org/10.1016/0002-9149(89)90450-5· OSTI ID:5820501

Younis, L T; Byers, S; Shaw, L; Barth, G; Goodgold, H; Chaitman, B R

Seventy-seven patients recovering from an acute coronary event were studied by intravenous dipyridamole thallium scintigraphy to evaluate the prognostic value and safety of the test in this patient subset. Forty-four patients (58%) had unstable angina and 33 (42%) had an acute myocardial infarction. One death occurred within 24 hours of testing. Sixty-eight patients were followed for an average of 12 months; 25, 31 and 23% had a fixed, reversible or combined thallium defect on their predischarge thallium scan. During follow-up, 10 patients died or had a nonfatal myocardial infarction; in each case, a reversible or combined myocardial thallium defect was present. Univariate analysis of 17 clinical, scintigraphic and angiographic variables showed that a reversible thallium defect and the angiographically determined extent of coronary artery disease were predictors of future cardiac events. The extent of coronary disease and global left ventricular ejection fraction were predictors of subsequent reinfarction or death. Logistic regression analyses revealed that a reversible thallium defect (p less than 0.001) and the extent of coronary disease (p less than 0.009) were the only significant predictors of a cardiac event. When death or reinfarction were the outcome variables, the extent of coronary disease (p less than 0.02) and left ventricular ejection fraction (p less than 0.06) were the only variables selected. Thus, intravenous dipyridamole thallium scintigraphy after an acute coronary ischemic syndrome is a useful and relatively safe noninvasive test to predict subsequent cardiac events.

• Research Organization: St. Louis Univ. School of Medicine, MO (USA)
• OSTI ID: 5820501
• Journal Information: Am. J. Cardiol.; (United States), Journal Name: Am. J. Cardiol.; (United States) Vol. 64:3; ISSN AJCDA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGRAMS
DISEASES
DRUGS
ELECTROCARDIOGRAMS
FORECASTING
HEART
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
MATHEMATICS
MYOCARDIAL INFARCTION
ORGANS
RADIOISOTOPE SCANNING
REGRESSION ANALYSIS
SCINTISCANNING
STATISTICS
THALLIUM ISOTOPES
VASODILATORS