Study of lung cancer histologic types, occupation, and smoking in Missouri

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Am. J. Ind. Med.; (United States)

DOI:https://doi.org/10.1002/ajim.4700150509· OSTI ID:5814748

Zahm, S H; Brownson, R C; Chang, J C; Davis, J R

A case-control study of lung cancer was conducted to evaluate the relationship between lung cancer histologic types and occupation, adjusted for smoking. A total of 4,431 white male cases and 11,326 cancer controls, diagnosed between 1980 and 1985, were identified through the Missouri Cancer Registry. For all histologic types combined, excess risk was observed among many a priori suspected high-risk occupations. Lung cancer was elevated among men employed as insulators (odds ratio (OR) = 6.0; 95% confidence interval (CI) = 0.7, 137.8), carpenters (OR = 1.3; 95% CI = 1.0, 1.7), painters, plasterers, and wallpaper hangers (OR = 2.0; 95% CI = 1.2,3.3), structural metal workers (OR = 1.9; 95% CI = 0.6,6.0), mechanics and repairers (OR = 1.3; 95% CI = 1.0,1.7), motor vehicle drivers (OR = 1.5; 95% CI = 1.2,1.8), police and firefighters (OR = 1.6; 95% CI = 1.1,2.3), and food service personnel (OR = 1.8; 95% CI = 1.0,3.5). A deficit of lung cancer was observed among farmers (OR = 0.9; 95% CI = 0.7,1.0). Adenocarcinoma of the lung was elevated among carpenters (OR = 1.6; 95% CI = 1.0,2.5) and cabinet and furniture makers (OR = 2.0; 95% CI = 0.4,8.1), which is interesting because of the previous reports of excess adenocarcinoma of the nasal cavity associated with wood dust exposure. Adenocarcinomas were also elevated among plumbers (OR = 2.0; 95% CI = 1.0,3.8) and printers (OR = 1.8; 95% CI = 0.7,4.2). Electricians were at slightly increased risk for adenocarcinoma (OR = 1.5; 95% CI = 0.7,2.8) and ''other'' or mixed cell types of lung cancer (OR = 1.5; 95% CI = 0.8,2.9) but at decreased risk for small cell (OR = 0.8; 95% CI = 0.3,2.0) and squamous cell (OR = 0.8; 95% CI = 0.4,1.6) tumors. Among welders, adenocarcinoma (OR = 1.7; 95% CI = 0.7,3.8) and squamous cell (OR = 1.7; 95% CI = 0.9,3.3) cancers were elevated, but small cell and ''other'' lung cancers were not.

• Research Organization: National Cancer Institute, Rockville, MD (USA)
• OSTI ID: 5814748
• Journal Information: Am. J. Ind. Med.; (United States), Journal Name: Am. J. Ind. Med.; (United States) Vol. 15:5; ISSN AJIMD
• Country of Publication: United States
• Language: English

Related Subjects

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560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BODY
CARCINOGENESIS
CARCINOMAS
COATINGS
COLLOIDS
DISEASES
DISPERSIONS
DUSTS
ELEMENTS
EPIDEMIOLOGY
FABRICATION
FEDERAL REGION VII
HAZARDS
HEALTH HAZARDS
JOINING
LUNGS
MAMMALS
MAN
METALS
MISSOURI
NEOPLASMS
NORTH AMERICA
OCCUPATIONAL EXPOSURE
ORGANS
PAINTS
PATHOGENESIS
PRIMATES
RESIDUES
RESPIRATORY SYSTEM
RISK ASSESSMENT
SMOKES
SOLS
TOBACCO SMOKES
USA
VERTEBRATES
WELDING
WOOD