Use of bioassay procedures for assessment of internal radionuclide deposition

Book · Thu Jan 01 04:00:00 EST 1987

OSTI ID:5814167

The development of very high resolution solid state detectors, multi-channel analyzers, computer systems, and metabolic models for the reference man have made possible the routine use of bioassay procedures for assessing internal deposition of radionuclides. However, frequently unanswered are questions such as what bioassay is, why it should be done, on whom should it be done, ways in which it can be done, how often it should be done, and how the results might be interpreted. This report addresses these questions. The report recognizes the limitations of bioassay procedures as a means of estimating the dose equivalent from internally deposited radionuclides. Estimates of radionuclide intakes or body (organ) burdens and their associated dose equivalents are limited by errors in the measurements made, uncertainties in the models used to interpret the results, and variability among subjects in radionuclide metabolism and dosimetry. These problems are addressed and references are provided for additional information.

• OSTI ID: 5814167
• Country of Publication: United States
• Language: English

Related Subjects

440100 -- Radiation Instrumentation
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560161 -- Radionuclide Effects
Kinetics
& Toxicology-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSTRACTS
BIOASSAY
BIOLOGICAL LOCALIZATION
COMPUTERIZED CONTROL SYSTEMS
CONTROL SYSTEMS
DIAGNOSTIC USES
DOCUMENT TYPES
DOSIMETRY
ELECTRONIC EQUIPMENT
EQUIPMENT
ISOTOPES
LABELLED COMPOUNDS
LEADING ABSTRACT
MEASURING INSTRUMENTS
METABOLISM
MULTI-CHANNEL ANALYZERS
PULSE ANALYZERS
RADIATION DETECTORS
RADIOISOTOPES
RADIONUCLIDE KINETICS
SCINTILLATION COUNTERS
SENSITIVITY
SOLID SCINTILLATION DETECTORS
USES