Mortality patterns among men exposed to methyl methacrylate

Journal Article · Sun Jan 01 04:00:00 EST 1989 · JOM, J. Occup. Med.; (United States)

OSTI ID:5814166

Collins, J J; Page, L C; Caporossi, J C; Utidjian, H M; Saipher, J N

A cohort of 2,671 men, 1561 of whom were exposed to methyl methacrylate, was observed from 1951 to 1983 for mortality. This cohort consisted of men from two plants. This study utilizes detailed exposure estimates and smoking status to evaluate mortality patterns. We find no statistically significant excess all-cause or cause-specific mortality. Analysis of dose of methyl methacrylate with several cancer sites showed no trend. Men exposed to high levels of methyl methacrylate had cancer rates similar to those for men not exposed in the workplace, as well as for other men in the US population. An earlier epidemiology study reported a significant excess of colorectal cancer among persons exposed to several substances including methyl methacrylate. Our study results and results from animal studies do not support the hypothesis that methyl methacrylate is a human carcinogen.

• Research Organization: American Cyanamid Company, Wayne, NJ (USA)
• OSTI ID: 5814166
• Journal Information: JOM, J. Occup. Med.; (United States), Journal Name: JOM, J. Occup. Med.; (United States) Vol. 31:1; ISSN JJOMD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
CARBOXYLIC ACID ESTERS
CHEMICAL INDUSTRY
DISEASES
ESTERS
INDUSTRY
METHACRYLIC ACID ESTERS
METHYL METHACRYLATE
MORTALITY
NEOPLASMS
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
PERSONNEL
POLLUTION
RISK ASSESSMENT
TOXICITY