Characterization of mouse cellular deoxyribonucleic acid homologous to Abelson murine leukemia virus-specific sequences
Journal Article
·
· Mol. Cell. Biol.; (United States)
The genome of Abelson murine leukemia virus (A-MuLV) consists of sequences derived from both BALB/c mouse deoxyribonucleic acid and the genome of Moloney murine leukemia virus. Using deoxyribonucleic acid linear intermediates as a source of retroviral deoxyribonucleic acid, we isolated a recombinant plasmid which contained 1.9 kilobases of the 3.5-kilobase mouse-derived sequences found in A-MuLV (A-MuLV-specific sequences). The authors used this clone, designated pSA-17, as a probe restriction enzyme and Southern blot analyses to examine the arrangement of homologous sequences in BALB/c deoxyribonucleic acid (endogenous Abelson sequences). Endogenous Abelson sequences were arranged similarly in mice that were susceptible to A-MuLV tumors and in mice that were resistant to A-MuLV tumors. An examination of three BALB/c plasmacytomas and a BALB/c early B-cell tumor likewise revealed no alteration in the arrangement of the endogenous Abelson sequences. Homology to pSA-17 was also observed in deoxyribonucleic acids prepared from rat, hamster, chicken, and human cells.
- Research Organization:
- Dept. of Microbiology, Univ. of Texas Health Science Center at Dallas, Dallas, TX 75235
- OSTI ID:
- 5809710
- Journal Information:
- Mol. Cell. Biol.; (United States), Journal Name: Mol. Cell. Biol.; (United States) Vol. 1:8; ISSN MCEBD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550400* -- Genetics
550700 -- Microbiology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BIRDS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CELL CONSTITUENTS
CELL TRANSFORMATIONS
CHICKENS
CLONING
DNA
DNA SEQUENCING
DNA-CLONING
ELECTROPHORESIS
ENZYMES
FOWL
FUNCTIONS
GENETIC MAPPING
GENOME MUTATIONS
HAMSTERS
LEUKEMIA VIRUSES
MAMMALS
MAN
MAPPING
MATERIALS
MICE
MICROORGANISMS
MUTATIONS
NUCLEIC ACIDS
ONCOGENIC TRANSFORMATIONS
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
PARASITES
PHOSPHOPROTEINS
PLASMIDS
PRIMATES
PROTEINS
RATS
RECOMBINANT DNA
RODENTS
SPECIFICITY
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES
VIRUSES
550700 -- Microbiology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BIRDS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CELL CONSTITUENTS
CELL TRANSFORMATIONS
CHICKENS
CLONING
DNA
DNA SEQUENCING
DNA-CLONING
ELECTROPHORESIS
ENZYMES
FOWL
FUNCTIONS
GENETIC MAPPING
GENOME MUTATIONS
HAMSTERS
LEUKEMIA VIRUSES
MAMMALS
MAN
MAPPING
MATERIALS
MICE
MICROORGANISMS
MUTATIONS
NUCLEIC ACIDS
ONCOGENIC TRANSFORMATIONS
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
PARASITES
PHOSPHOPROTEINS
PLASMIDS
PRIMATES
PROTEINS
RATS
RECOMBINANT DNA
RODENTS
SPECIFICITY
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES
VIRUSES