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Noninvasive method for measuring portal venous/total hepatic blood flow by hepatosplenic radionuclide angiography

Journal Article · · Radiology; (United States)
; ;

Radionuclide angiography was used to generate first-phase radioactivity vs. time curves for the left heart, right hepatic lobe, right lung, spleen, and both kidneys following rapid intravenous injection of 20 mCi (740MBq) of /sup 99m/Tc-pertechnetate. Seven normal subjects were examined as well as 57 cirrhotic patients, who also underwent angiographic grading of portal venous perfusion. For analysis, two time points were identified: (a) t/sub o/, when /sup 99m/Tc first entered the liver (the initial rise of either curve); and (b) t/sub c/, when /sup 99m/Tc was maximal in abdominal organs (the renal peak). Analysis was based on the slopes of the two phases of the hepatic curves t/sub o/ + 7 seconds and t/sub c/ + 7 seconds; this time selection permitted analysis of all curves. The hepatic perfusion index (HPI) = slope (t/sub c/ + 7 secs)/slope (t/sub o/ + 7 secs) + slope (t/sub c/ + 7 secs). The mean HPI for the normal subjects was 66% +- 7; for the cirrhotic patients with angiograhic Grades I, II, III, and IV, the HPI was 52% +- 9, 37% +- 6, 15% +- 7, and 3% +- 4, respectively. Correlation between HPI and angiography was significant (p < 0.001). This method offers a readily available, rapid, relatively inexpensive, and quantitative method of grading the ratio of portal venous to total hepatic blood flow.

Research Organization:
Emory Univ., Atlanta, GA
OSTI ID:
5808291
Journal Information:
Radiology; (United States), Journal Name: Radiology; (United States) Vol. 141:1; ISSN RADLA
Country of Publication:
United States
Language:
English

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Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM DISEASES
DISEASES
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LIVER CIRRHOSIS
LUNGS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
PORTAL SYSTEM
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SCINTISCANNING
SPLEEN
TECHNETIUM 99
TECHNETIUM ISOTOPES
VEINS
YEARS LIVING RADIOISOTOPES