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Growth patterns of the offspring of alcohol-fed rats

Journal Article · · Growth, Development and Aging; (United States)
OSTI ID:5805248
; ;  [1]
  1. Chicago Medical School, IL (United States) Veterans Administration Medical Center, North Chicago, IL (United States)
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The role of altered glucose metabolism in the growth retardation associated with the Fetal Alcohol Syndrome has been difficult to assess because previously used experimental procedures have frequently substituted ethanol for dietary carbohydrate. Consequently, there is a severe reduction of the carbohydrate content of the diet. This study examined brain and liver development at 7, 15, 21, and 42 days of age in the male offspring of ethanol-fed rats which received a liquid diet in which carbohydrate and protein content were equal to that of the control diet. Ethanol provided 30% of the daily calories and was substituted isocalorically and the mean brain weight of the offspring of these ethanol-fed rats were significantly lower than controls at all ages studied, and the mean brain weight was decreased at 7 and 15 days of age but not subsequently. Brain protein content was significantly lower in the experimental group at 7 and 15 days of age, and liver protein content was reduced at 15, 21, and 42 days of age. The DNA content was not affected in either organ by exposure to ethanol in utero. Increasingly carbohydrate and total caloric intake moderates, but does not eliminate, the effects of maternal ethanol ingestion on offspring growth.
OSTI ID:
5805248
Journal Information:
Growth, Development and Aging; (United States), Journal Name: Growth, Development and Aging; (United States) Vol. 52:2; ISSN 1041-1232; ISSN GDAGE
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ALDEHYDES
ANIMAL GROWTH
ANIMALS
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
DNA
ETHANOL
GLANDS
GLUCOSE
GROWTH
HEXOSES
HYDROXY COMPOUNDS
LIVER
MAMMALS
METABOLISM
MONOSACCHARIDES
NEONATES
NERVOUS SYSTEM
NUCLEIC ACIDS
ONTOGENESIS
ORGANIC COMPOUNDS
ORGANS
PRENATAL EXPOSURE
RATS
RODENTS
SACCHARIDES
TOXICITY
VERTEBRATES
WEIGHT