Cyclotron production of [{sup 18}F]fluoride ion and [{sup 18}F]fluorine gas and their medical applications

Journal Article · Sat Feb 01 04:00:00 EST 1997 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.52645· OSTI ID:580135

VanBrocklin, H F; ONeil, J P ^[1]

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1. Center for Functional Imaging, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720 (United States)

One of the newest low energy cyclotrons for the production of positron emitting isotopes has been sited at Lawrence Berkeley National Laboratory. This prototype CTI RDS-111, proton only, 11 MeV, negative ion machine is capable of producing GBq quantities of fluorine-18 for radiopharmaceutical applications. A CTI designed target changing system developed for this cyclotron can hold up to eight small targets. We have tested two small high pressure CTI silver body target designs for the production of [{sup 18}F]fluoride ion and compared them to the CTI RDS-112 style low pressure target. The high pressure target can produce up to 100{percent} more activity for a given time and beam current with improved saturation yields. A high pressure aluminum RDS-112 gas target has been used to produce [{sup 18}F]F{sub 2}. The fluoride ion produced from this machine has been used to label fluorodeoxyglucose to trace glucose metabolism in patients and the fluorine gas has been used to label fluoro-meta-tyrosine to image therapeutic response to gene therapy in Parkinsonian monkeys. {copyright} {ital 1997 American Institute of Physics.}

• Research Organization: Lawrence Berkeley National Laboratory
• Sponsoring Organization: USDOE
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 580135
• Report Number(s): CONF-961110--
• Journal Information: AIP Conference Proceedings, Journal Name: AIP Conference Proceedings Journal Issue: 1 Vol. 392; ISSN APCPCS; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

43 PARTICLE ACCELERATORS
55 BIOLOGY AND MEDICINE
BASIC STUDIES
BEAM CURRENTS
CYCLOTRONS
FLUORINE 18
ISOTOPE PRODUCTION
POSITRON COMPUTED TOMOGRAPHY
PRESSURE DEPENDENCE
PROTON BEAMS
TARGETS