Cerebral blood flow response to changes in arterial carbon dioxide tension during hypothermic cardiopulmonary bypass in children

Journal Article · Mon Apr 01 04:00:00 EST 1991 · Journal of Thoracic and Cardiovascular Surgery; (USA)

OSTI ID:5800969

Kern, F H; Ungerleider, R M; Quill, T J; Baldwin, B; White, W D; Reves, J G; Greeley, W J ^[1]

---

1. Duke Univ. Medical Center, Durham, NC (USA)

We examined the relationship of changes in partial pressure of carbon dioxide on cerebral blood flow responsiveness in 20 pediatric patients undergoing hypothermic cardiopulmonary bypass. Cerebral blood flow was measured during steady-state hypothermic cardiopulmonary bypass with the use of xenon 133 clearance methodology at two different arterial carbon dioxide tensions. During these measurements there was no significant change in mean arterial pressure, nasopharyngeal temperature, pump flow rate, or hematocrit value. Cerebral blood flow was found to be significantly greater at higher arterial carbon dioxide tensions (p less than 0.01), so that for every millimeter of mercury rise in arterial carbon dioxide tension there was a 1.2 ml.100 gm-1.min-1 increase in cerebral blood flow. Two factors, deep hypothermia (18 degrees to 22 degrees C) and reduced age (less than 1 year), diminished the effect carbon dioxide had on cerebral blood flow responsiveness but did not eliminate it. We conclude that cerebral blood flow remains responsive to changes in arterial carbon dioxide tension during hypothermic cardiopulmonary bypass in infants and children; that is, increasing arterial carbon dioxide tension will independently increase cerebral blood flow.

• OSTI ID: 5800969
• Journal Information: Journal of Thoracic and Cardiovascular Surgery; (USA), Journal Name: Journal of Thoracic and Cardiovascular Surgery; (USA) Vol. 101:4; ISSN 0022-5223; ISSN JTCSA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE GROUPS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD PRESSURE
BODY
BODY TEMPERATURE
BRAIN
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
CHALCOGENIDES
CHILDREN
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
HEART
HYPOTHERMIA
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
NERVOUS SYSTEM
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PARTIAL PRESSURE
PATIENTS
RADIOISOTOPES
SURGERY
XENON 133
XENON ISOTOPES