Heart imaging with cationic complexes of technetium
Journal Article
·
· Science (Washington, D.C.); (United States)
- Univ. of Cincinnati, Cincinnati, OH
The cationic technetium-99 complex trans-(/sup 99/Tc(dmpe)/sub 2/Cl/sub 2/)/sup +/, where dmpe is bis(1,2-dimethylphosphino)ethane or (CH/sub 3/)/sub 2/P-CH/sub 2/CH/sub 2/-P(CH/sub 3/)/sub 2/, has been prepared and characterized by single-crystal, x-ray structural analysis. The technetium-99m analog, trans-(/sup 99m/Tc (dmpe)/sub 2/Cl/sub 2/)/sup +/, has also been prepared and shown to yield excellent gamma-ray images of the heart. The purposeful design, characterization, and synthesis of this technetium-99m radiopharmaceutical represents a striking application of fundamental inorganic chemistry to a problem in applied nuclear medicine.
- OSTI ID:
- 5800889
- Journal Information:
- Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 214; ISSN SCIEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Studies in technetium chemistry applied to the practice of diagnostic nuclear medicine
Thiolato-technetium complexes. 1. Synthesis and characterization of bis(tertiary diphosphine)technetium(III) complexes containing methanethiolato ligands. Single-crystal structural analyses of trans-(Tc/sup III/(SCH/sub 3/)/sub 2/(DMPE)/sub 2/)CF/sub 3/SO/sub 3/ and trans-(Tc/sup III/(SCH/sub 3/)/sub 2/(DEPE)/sub 2/)PF/sub 6/, where DMPE = 1,2-bis(dimethylphosphino)ethane and DEPE = 1,2-bis(diethylphosphino)ethane
Synthesis and characterization of cationic technetium complexes of 1,2-bis(dimethylphosphino)ethane (DMPE): structure determinations of trans-(Tc/sup v/(DMPE)/sub 2/(OH)(O))(F/sub 3/CSO/sub 3/)/sub 2/, trans-(Tc/sup III/(DMPE)/sub 2/Cl/sub 2/)F/sub 3/CSO/sub 3/, and (Tc/sup I/(DMPE)/sub 3/)/sup +/ using x-ray diffraction, EXAFS, and /sup 99/Tc NMR
Thesis/Dissertation
·
Wed Dec 31 23:00:00 EST 1980
·
OSTI ID:5672453
Thiolato-technetium complexes. 1. Synthesis and characterization of bis(tertiary diphosphine)technetium(III) complexes containing methanethiolato ligands. Single-crystal structural analyses of trans-(Tc/sup III/(SCH/sub 3/)/sub 2/(DMPE)/sub 2/)CF/sub 3/SO/sub 3/ and trans-(Tc/sup III/(SCH/sub 3/)/sub 2/(DEPE)/sub 2/)PF/sub 6/, where DMPE = 1,2-bis(dimethylphosphino)ethane and DEPE = 1,2-bis(diethylphosphino)ethane
Journal Article
·
Tue Nov 15 23:00:00 EST 1988
· Inorg. Chem.; (United States)
·
OSTI ID:5761950
Synthesis and characterization of cationic technetium complexes of 1,2-bis(dimethylphosphino)ethane (DMPE): structure determinations of trans-(Tc/sup v/(DMPE)/sub 2/(OH)(O))(F/sub 3/CSO/sub 3/)/sub 2/, trans-(Tc/sup III/(DMPE)/sub 2/Cl/sub 2/)F/sub 3/CSO/sub 3/, and (Tc/sup I/(DMPE)/sub 3/)/sup +/ using x-ray diffraction, EXAFS, and /sup 99/Tc NMR
Journal Article
·
Wed Sep 26 00:00:00 EDT 1984
· Inorg. Chem.; (United States)
·
OSTI ID:6054127
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOGRAPHY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CATIONS
CHARGED PARTICLES
CHEMICAL PREPARATION
COMPLEXES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IONS
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MEASURING METHODS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOCARDIOGRAPHY
RADIOISOTOPES
RADIOPHARMACEUTICALS
SYNTHESIS
TECHNETIUM 99
TECHNETIUM COMPLEXES
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPLEXES
UPTAKE
YEARS LIVING RADIOISOTOPES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOGRAPHY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CATIONS
CHARGED PARTICLES
CHEMICAL PREPARATION
COMPLEXES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IONS
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MEASURING METHODS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOCARDIOGRAPHY
RADIOISOTOPES
RADIOPHARMACEUTICALS
SYNTHESIS
TECHNETIUM 99
TECHNETIUM COMPLEXES
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPLEXES
UPTAKE
YEARS LIVING RADIOISOTOPES