Suppressive effects of 3-methylcholanthrene on the in vitro antitumor activity of naturally cytotoxic cells
Transient suppression of splenic natural killer (NK), natural cytotoxic (NC) and peritoneal macrophage cytotoxicity was observed following a single injection of 3-methylcholanthrene (3-MC) into C3H/HeN mice. Natural killer cell activity was depressed by 30-60% 4-6 d after injection of 1.0 mg 3-MC. Levels of NK reactivity returned to normal 8 d post 3-MC injection, and no suppression of natural killing was seen when tested 6 wk after 3-MC treatment. 3-MC did not affect propionibacterium acnes augmentation of NK cell activity when tested both 6 d and 6 wk after carcinogen injection. The results indicate that the observed suppression of naturally cytotoxic cells may not be important in allowing 3-MC-induced tumors to grow, since suppression is not long-lasting. Therefore, any effect on tumor growth mediated by a suppression of naturally cytotoxic cells would have to be exerted at the earliest stages of tumor development.
- Research Organization:
- Univ. of South Carolina, Columbia
- OSTI ID:
- 5800422
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 17:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
3-METHYLCHOLANTHRENE
CARCINOGENESIS
MICE
IMMUNOSUPPRESSION
TUMOR CELLS
CELL KILLING
IN VITRO
INHIBITION
LEUKOCYTES
MACROPHAGES
NEOPLASMS
TIME DEPENDENCE
ANIMAL CELLS
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
HYDROCARBONS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
PATHOGENESIS
PHAGOCYTES
POLYCYCLIC AROMATIC HYDROCARBONS
RODENTS
SOMATIC CELLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)