The effects of sucralfate suspension and diphenhydramine syrup plus kaolin-pectin on radiotherapy-induced mucositis

Journal Article · Fri Mar 01 04:00:00 EST 1991 · Oral Surgery, Oral Medicine, Oral Pathology; (USA)

DOI:https://doi.org/10.1016/0030-4220(91)90301-R· OSTI ID:5800143

Barker, G; Loftus, L; Cuddy, P; Barker, B ^[1]

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1. Univ. of Missouri, Kansas City (USA)

A prospective, double-blind study compared the effectiveness of sucralfate suspension with diphenhydramine syrup plus kaolin-pectin in reducing severity and pain of radiation-induced oropharyngeal mucositis. Fourteen patients who received at least 4600 cGy to the oral cavity used one of the mouth rinses four times a day, beginning at 1600 cGy. Data were collected on daily perceived pain and helpfulness of mouth rinse, weekly mucositis grade, weight change, and interruption of therapy. Analysis of data revealed no statistically significant differences between the two groups in any parameter. A retrospective review of 15 patients who had received at least 4600 cGy radiation to the oropharynx but had not used a daily mouth-coating rinse, was compared with the study group. Comparison of the two groups suggested that consistent daily oral hygiene and use of a mouth-coating agent will result in less pain and may reduce weight loss and interruption of radiation because of severe mucositis.

• OSTI ID: 5800143
• Journal Information: Oral Surgery, Oral Medicine, Oral Pathology; (USA), Journal Name: Oral Surgery, Oral Medicine, Oral Pathology; (USA) Vol. 71:3; ISSN OSOMA; ISSN 0030-4220
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD SUBSTITUTES
CARBOHYDRATES
CLAYS
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
DOSES
DRUGS
HEMATOLOGIC AGENTS
KAOLIN
MEDICINE
MEMBRANES
MUCOUS MEMBRANES
NUCLEAR MEDICINE
ORAL CAVITY
ORGANIC COMPOUNDS
PAIN
PATHOLOGICAL CHANGES
PECTINS
POLYSACCHARIDES
RADIATION DOSES
RADIATION EFFECTS
RADIOLOGY
RADIOSENSITIZERS
RADIOTHERAPY
SACCHARIDES
SIDE EFFECTS
SYMPTOMS
THERAPY