Scintigraphic characteristics of experimental myocardial infarct extension. [/sup 99m/Tc, dogs]

Journal Article · Wed Oct 31 23:00:00 EST 1979 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.60.5.1130· OSTI ID:5798264

Kronenberg, M W; Wooten, N E; Friesinger, G C; Page, D L; Higgins, S B; Collins, J C; O'Connor, J L; Price, R R; Brill, A B

Technetium-99m-stannous pyrophosphate scintiphotos were evaluated for diagnosing and quantitating myocardial infarct (MI) extension in sedated dogs. Infarction and extension were produced by serial left anterior descending coronary artery ligations at 0 and 48 hours. We compared serial scintiphoto data with regional myocardial blood flow (MBF) (microsphere technique) and infarct histopathology. In eight control dogs, the scintigraphic MI area was stable at 24, 48, and 72 hours. In each of 11 dogs undergoing extension, the MI area increased after the 48-hour occlusion, averaging a 48.9% increase (p < 0.001). Grossly, most extensions were mixtures of confluent necrosis and moderate (patchy) necrosis. MBF to confluent infarct tissue decreased significantly, allowing the documentation of extension by totaling the grams of newly flow-deprived tissue, but patchy infarct tissue had little flow deprivation, making it difficult to quantitate this type of extension accurately by flow criteria alone. Rarely, extension could be diagnosed using conventional histologic criteria. We concluded that the scintiphoto MI area was related quantitatively to infarct weight in both control and extension. However, it was not possible to determine that an increase in the MI scintiphoto area was an accurate predictor of the degree of extension using independent flow or pathologic criteria.

• Research Organization: Vanderbilt University Medical Center, Nashvile, TN
• OSTI ID: 5798264
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 60:5; ISSN CIRCA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPLEXES
COUNTING TECHNIQUES
DATA
DATA FORMS
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
EXPERIMENTAL DATA
HEART
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOLATED VALUES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
PYROPHOSPHATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SURGERY
TECHNETIUM 99
TECHNETIUM ISOTOPES
TIN COMPLEXES
VERTEBRATES
WEIGHT MEASUREMENT
YEARS LIVING RADIOISOTOPES