Naltrexone pretreatment blocks microwave-induced changes in central cholinergic receptors

Journal Article · Mon Dec 31 23:00:00 EST 1990 · Bioelectromagnetics (New York); (USA)

DOI:https://doi.org/10.1002/bem.2250120105· OSTI ID:5797224

Lai, H; Carino, M A; Wen, Y F; Horita, A; Guy, A W ^[1]

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1. Univ. of Washington School of Medicine, Seattle (USA)

Repeated exposure of rats to pulsed, circularly polarized microwaves (2,450-MHz, 2-microseconds pulses at 500 pps, power density 1 mW/cm2, at an averaged, whole-body SAR of 0.6 W/kg) induced biphasic changes in the concentration of muscarinic cholinergic receptors in the central nervous system. An increase in receptor concentration occurred in the hippocampus of rats subjected to ten 45-min sessions of microwave exposure, whereas a decrease in concentration was observed in the frontal cortex and hippocampus of rats exposed to ten 20-min sessions. These findings, which confirm earlier work in the authors' laboratory, were extended to include pretreatment of rats with the narcotic antagonist naltrexone (1 mg/kg, IP) before each session of exposure. The drug treatment blocked the microwave-induced changes in cholinergic receptors in the brain. These data further support the authors' hypothesis that endogenous opioids play a role in the effects of microwaves on central cholinergic systems.

• OSTI ID: 5797224
• Journal Information: Bioelectromagnetics (New York); (USA), Journal Name: Bioelectromagnetics (New York); (USA) Journal Issue: 1 Vol. 12:1; ISSN BLCTD; ISSN 0197-8462
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETYLCHOLINE
AMINES
AMMONIUM COMPOUNDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DRUGS
ELECTROMAGNETIC RADIATION
ENDORPHINS
ESTERS
FUNCTIONS
MAMMALS
MEMBRANE PROTEINS
MICROWAVE RADIATION
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOMIMETICS
PROTEINS
QUATERNARY COMPOUNDS
RADIATIONS
RATS
RECEPTORS
RODENTS
VERTEBRATES