Effect of sulfur dioxide on the morphology and mucin biosynthesis by the rat trachea
Journal Article
·
· J. Environ. Pathol. Toxicol.; (United States)
OSTI ID:5793160
Specific-pathogen-free rats were exposed to 400 ppM sulfur dioxide daily for up to 7 weeks. At intervals during exposure, tracheas were removed and incubated in vitro in culture medium containing radioactive glycoprotein precursors. The most prominent histological changes due to SO/sub 2/ were progressive hypertrophy and hyperplasia of the submucosal mucous glands accompanied by a flattening of the epithelium with eventual recovery. Uptake of radioactive precursors into a highly purified mucin fraction correlated with these histological changes in the submucosal mucous glands, increasing progressively up to 4 times that of control. Uptake of precursors into specific mucins purified by DEAE-Sephacel showed that uptake into the 0.2 and 0.3 M NaCl fractions was stimulated several fold by SO/sub 2/, and uptake into more highly acidic fractions, which was nearly absent in the control, was also greatly increased. Two weeks following the last exposure of the tracheas to SO/sub 2/, their morphological and mucus-secreting properties showed signs of returning to that of the control.
- Research Organization:
- Univ. of Tennessee, Oak Ridge
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5793160
- Journal Information:
- J. Environ. Pathol. Toxicol.; (United States), Journal Name: J. Environ. Pathol. Toxicol.; (United States) Vol. 4; ISSN JEPTD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550300 -- Cytology
551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOSYNTHESIS
CARBOHYDRATES
CHALCOGENIDES
CHRONIC EXPOSURE
EXPOSURE CHAMBERS
GERM-FREE ANIMALS
INHALATION
INTAKE
MAMMALS
MEMBRANES
MORPHOLOGICAL CHANGES
MUCOPROTEINS
MUCOUS MEMBRANES
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
POLYSACCHARIDES
PROTEINS
RATS
RECOVERY
RESPIRATORY SYSTEM
RODENTS
SACCHARIDES
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
SYNTHESIS
TRACHEA
VERTEBRATES
551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOSYNTHESIS
CARBOHYDRATES
CHALCOGENIDES
CHRONIC EXPOSURE
EXPOSURE CHAMBERS
GERM-FREE ANIMALS
INHALATION
INTAKE
MAMMALS
MEMBRANES
MORPHOLOGICAL CHANGES
MUCOPROTEINS
MUCOUS MEMBRANES
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
POLYSACCHARIDES
PROTEINS
RATS
RECOVERY
RESPIRATORY SYSTEM
RODENTS
SACCHARIDES
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
SYNTHESIS
TRACHEA
VERTEBRATES