Effect of sulfur dioxide on the morphology and mucin biosynthesis by the rat trachea
Specific-pathogen-free rats were exposed to 400 ppM sulfur dioxide daily for up to 7 weeks. At intervals during exposure, tracheas were removed and incubated in vitro in culture medium containing radioactive glycoprotein precursors. The most prominent histological changes due to SO/sub 2/ were progressive hypertrophy and hyperplasia of the submucosal mucous glands accompanied by a flattening of the epithelium with eventual recovery. Uptake of radioactive precursors into a highly purified mucin fraction correlated with these histological changes in the submucosal mucous glands, increasing progressively up to 4 times that of control. Uptake of precursors into specific mucins purified by DEAE-Sephacel showed that uptake into the 0.2 and 0.3 M NaCl fractions was stimulated several fold by SO/sub 2/, and uptake into more highly acidic fractions, which was nearly absent in the control, was also greatly increased. Two weeks following the last exposure of the tracheas to SO/sub 2/, their morphological and mucus-secreting properties showed signs of returning to that of the control.
- Research Organization:
- Univ. of Tennessee, Oak Ridge
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5793160
- Journal Information:
- J. Environ. Pathol. Toxicol.; (United States), Vol. 4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
MUCOUS MEMBRANES
PATHOLOGICAL CHANGES
SULFUR DIOXIDE
BIOLOGICAL EFFECTS
TRACHEA
MORPHOLOGICAL CHANGES
BIOLOGICAL RECOVERY
BIOSYNTHESIS
CHRONIC EXPOSURE
EXPOSURE CHAMBERS
GERM-FREE ANIMALS
INHALATION
MUCOPROTEINS
RATS
ANIMALS
CARBOHYDRATES
CHALCOGENIDES
INTAKE
MAMMALS
MEMBRANES
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
POLYSACCHARIDES
PROTEINS
RECOVERY
RESPIRATORY SYSTEM
RODENTS
SACCHARIDES
SULFUR COMPOUNDS
SULFUR OXIDES
SYNTHESIS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550300 - Cytology
551000 - Physiological Systems