The molecular and developmental biology of keratins

Book · Thu Jan 01 04:00:00 EST 1987

OSTI ID:5786707

Sawyer, R H

Keratins make up the intermediate filaments found in almost all epithelia from fish to mammals, and are the products of multigene families. The great diversity in the form and function of epithelia and the tissue-specific expression of the keratins with their ''pairing rules'' makes the study of epithelial differentiation an excellent paradigm for studying the development regulation of gene expression. This book discusses the following contents: Introduction; The Human Keratin Genes and Their Differential Expression; Expression and Modification of keratins during Terminal Differentiation of Mammalian Epidermis; The Experimental Manipulation of Keratin Expression and Organization in Epithelial Cells and Somatic Cells Hybrids; Patterns of Keratin Expression Define Distinct Pathways of Epithelial Development and Differentiation; Developmental Expression of Human Epidermal Keratins and Filaggrin; Cytokeratins in Oocytes and Preimplantation Embryos of the Mouse; Role of Epidermal Growth Factor in Embryonic Development; Regulation of Keratin Gene Expression during Differentiation of Epidermal and Vaginal Epithelial Cells; Abnormal Development in the Skin of the Pupoid Fetus (pf/pf) Mutant Mouse; Abnormal Keratinization, Recovery of a Normal Phenotype, and Relationship of the Repeated Epilation (Er) Mutant Mouse. Expression of B-Keratin Genes during Development of Avian Skin Appendages; Concluding Remarks and Future Directions. Each chapter includes references and index.

• OSTI ID: 5786707
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
BIOCHEMISTRY
BIOLOGICAL PATHWAYS
BODY
CELL DIFFERENTIATION
CHEMISTRY
DOCUMENT TYPES
EMBRYOS
EPIDERMIS
EPITHELIUM
FEMALE GENITALS
GENE REGULATION
GENES
GROWTH
GROWTH FACTORS
KERATIN
MAMMALS
MICE
MITOGENS
MOLECULAR BIOLOGY
MUTATIONS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
REVIEWS
RODENTS
SCLEROPROTEINS
SKIN
TISSUES
VERTEBRATES