Measurement of whole body cellular and collagen nitrogen, potassium, and other elements by neutron activation and whole body counting

Journal Article · Tue Sep 01 04:00:00 EDT 1987 · JPEN, J. Parenter. Enteral Nutr.; (United States)

DOI:https://doi.org/10.1177/014860718701100505· OSTI ID:5786089

James, H M; Fabricius, P J; Dykes, P W

Whole body nitrogen can be measured by neutron activation analysis with an acceptable radiation dose; it is an index of body protein which, in normal subjects, is 65% cellular protein and 35% extracellular connective collagen. Whole body potassium can be measured by whole body counting without irradiating the subject; it is an index of body cell mass. We measured whole body nitrogen, potassium, extracellular water, intracellular water, and fat-folds. The differences between 37 malnourished patients and five normal subjects suggested that the patients had 9 kg less cell mass than normal, but no difference in extracellular mass. Measurements were made on eight patients before and after 14 days of total parenteral nutrition; balance of nitrogen intake and excretion also was measured. The changes were consistent with mean increases of 3 kg of cellular mass and 3 kg of fat with no change of extracellular mass. The accuracy and sensitivity of the whole body measurements need further confirmation for use in patients with changing body composition. Where tissue wasting is largely from the cellular compartment, potassium could be a more sensitive index of wasting than nitrogen. Multielement analysis of nitrogen, potassium, chlorine, and carbon will probably be valuable in elucidating body composition in malnutrition.

• Research Organization: Queen Elizabeth Hospital, Birmingham, England
• OSTI ID: 5786089
• Journal Information: JPEN, J. Parenter. Enteral Nutr.; (United States), Journal Name: JPEN, J. Parenter. Enteral Nutr.; (United States) Vol. 11:5 Suppl; ISSN JPEND
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACTIVATION ANALYSIS
ALKALI METALS
BARYON REACTIONS
BODY COMPOSITION
CARBON
CHEMICAL ANALYSIS
CHLORINE COMPOUNDS
COLLAGEN
COUNTING TECHNIQUES
ELEMENTS
EXTRACELLULAR SPACE
HADRON REACTIONS
HALOGEN COMPOUNDS
HYDROGEN COMPOUNDS
METALS
NEUTRON REACTIONS
NITROGEN
NONMETALS
NUCLEAR REACTIONS
NUCLEON REACTIONS
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PATIENTS
POTASSIUM
PROTEINS
SCLEROPROTEINS
SPACE
WATER
WHOLE-BODY COUNTING