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/sup 45/Calcium uptake during the transition from reversible to irreversible liver injury induced by D-galactosamine in vivo

Journal Article · · Hepatology (N.Y.); (United States)
OSTI ID:5779000
; ;

The hepatic uptake of 45calcium (/sup 45/Ca) was studied in rats after administration of D-galactosamine (3 mmoles per kg, i.v.). In contrast to measurements of the hepatic calcium content, /sup 45/Ca uptake served as a dynamic rather than a static indicator of calcium homeostasis during the transition from reversible to irreversible liver injury which occurs between 3 and 4 hr after injection of the hepatotoxin. /sup 45/Ca uptake during a 1 hr-labeling period increased from 25 to 100% above control between 3 and 4 hr and subsequently remained at this level. The rise in /sup 45/Ca uptake and in hepatic calcium content occurred 2 to 3 hr after the D-galactosamine-induced depletion of UTP, UDP-galactose, UDP-glucose and UDP-glucuronate. The level of UDP-glucuronate was the earliest to recover. The enhanced /sup 45/Ca uptake was associated with hepatic glycogen breakdown and with an increased SGPT activity in plasma. Uridine, at a dose replenishing uracil nucleotide pools after their depletion by D-galactosamine, prevented or reversed the rise in /sup 45/Ca uptake. The antiinflammatory steroid dexamethasone, injected prior to or simultaneously with D-galactosamine also protected against the loss of calcium homeostasis and the development of liver injury.

Research Organization:
Univ. of Freiburg, Breisgau, West Germany
OSTI ID:
5779000
Journal Information:
Hepatology (N.Y.); (United States), Journal Name: Hepatology (N.Y.); (United States) Vol. 4:5; ISSN HEPAD
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ALDEHYDES
ALKALINE EARTH ISOTOPES
AMINES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CALCIUM 45
CALCIUM ISOTOPES
CARBOHYDRATES
CORTICOSTEROIDS
DAYS LIVING RADIOISOTOPES
DEXAMETHASONE
DIGESTIVE SYSTEM
EVEN-ODD NUCLEI
GALACTOSE
GLANDS
GLUCOCORTICOIDS
HEXOSES
HOMEOSTASIS
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
KETONES
LIVER
MAMMALS
MONOSACCHARIDES
NUCLEI
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
PREGNANES
RADIOISOTOPES
RATS
RODENTS
SACCHARIDES
STEROID HORMONES
STEROIDS
UPTAKE
UTP
VERTEBRATES