Busulfan and total body irradiation as antihematopoietic stem cell agents in the preparation of patients with congenital bone marrow disorders for allogenic bone marrow transplantation

Journal Article · Mon Oct 01 00:00:00 EDT 1984 · Blood; (United States)

OSTI ID:5777386

Parkman, R; Rappeport, J M; Hellman, S; Lipton, J; Smith, B; Geha, R; Nathan, D G

The capacity of busulfan and total body irradiation to ablate hematopoietic stem cells as preparation for the allogeneic bone marrow transplantation of patients with congenital bone marrow disorders was studied. Fourteen patients received 18 transplants; busulfan was used in the preparatory regimen of eight transplants and total body irradiation in the regimens of six transplants. Sustained hematopoietic ablation was achieved in six of eight patients prepared with busulfan and in all six patients prepared with total body irradiation. Three patients prepared with total body irradiation died with idiopathic interstitial pneumonitis, whereas no patients receiving busulfan developed interstitial pneumonitis. The optimal antihematopoietic stem cell agent to be used for the preparation of patients with congenital bone marrow disorder for bone marrow transplantation is not certain.

• Research Organization: Children's Hospital Medical Center, Boston, MA
• OSTI ID: 5777386
• Journal Information: Blood; (United States), Vol. 64:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW
TRANSPLANTS
IMMUNOSUPPRESSION
RADIOINDUCTION
MYLERAN
RADIOSENSITIVITY EFFECTS
PATIENTS
PNEUMONITIS
STEM CELLS
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ALKYLATING AGENTS
ANIMAL CELLS
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HEMATOPOIETIC SYSTEM
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560151* - Radiation Effects on Animals- Man