Radiotoxicity of thallium-201 in mouse testes: inadequacy of conventional dosimetry

Journal Article · Tue Feb 01 00:00:00 EST 1983 · J. Nucl. Med.; (United States)

OSTI ID:5776958

Rao, D V; Govelitz, G F; Sastry, K S

When TI-201 is concentrated in mouse testes, the low-energy Auger electrons following its electron-capture decay are found to be much more effective in causing loss of testicular weight and reduction of sperm heads than the energetic beta particles from similarly distributed TI-204. These results are contrary to expectations based on conventional dosimetry of tissue-incorporated radionuclides, and point to possible underestimation of risks by the currently adopted dosimetric procedures, especially in the case of radionuclides decaying by electron capture and internal conversion.

• Research Organization: Univ. of Medicine and Dentistry of New Jersey, Newark
• OSTI ID: 5776958
• Journal Information: J. Nucl. Med.; (United States), Vol. 24:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
TESTES
BIOLOGICAL RADIATION EFFECTS
THALLIUM 201
ELECTRON DOSIMETRY
AUGER EFFECT
DOSE-RESPONSE RELATIONSHIPS
INTERNAL CONVERSION
MICE
SPERMATOZOA
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CONVERSION
DAYS LIVING RADIOISOTOPES
DECAY
DOSIMETRY
ELECTRON CAPTURE RADIOISOTOPES
GAMETES
GERM CELLS
GONADS
HEAVY NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MALE GENITALS
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIATION EFFECTS
RADIOISOTOPES
RODENTS
SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
VERTEBRATES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells
550601 - Medicine- Unsealed Radionuclides in Diagnostics