Linear relationship between lethal mutation yield and intake of ethyl methanesulfonate in Drosophila melanogaster
Journal Article
·
· Environ. Mutagen.; (United States)
Males of Drosophila melanogaster were fed sucrose solutions containing various concentrations of EMS (from 0.25 to 10mM) for 24 hr. To measure the intake of an EMS solution, /sup 3/H-labeled sucrose was added to the feeding solution, and the /sup 3/H activity inside the flies was used as a measure for the intake volume of EMS solution. The relationship between the estimated absorbed dose and the exposure concentration was almost linear in a low concentration range but became concave with a downward curvature in a high concentration range. The dose-response relationship between the frequency of sex-linked recessive lethals and the estimated absorbed dose showed no deviation from linearity at all the five absorbed doses tested. It may be concluded that the absorbed doses thus estimated were very close to true absorbed doses, indicating the usefulness of the present method for dosimetry of chemicals to be given to files.
- Research Organization:
- Nagasaki Univ. School of Medicine, Japan
- OSTI ID:
- 5775138
- Journal Information:
- Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 7:2; ISSN ENMUD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Relationship between lethal mutation yield and intake of ethylnitrosourea (ENU) in Drosophila melanogaster
Contribution of ethyl methanesulfonate vapors to the yield of mutations detected in Drosophila melanogaster when the adult feeding technique is used
Method for selecting exposure levels for the Drosophila sex-linked recessive lethal assay
Journal Article
·
Sat Dec 31 23:00:00 EST 1983
· Environ. Mutagen.; (United States)
·
OSTI ID:6219711
Contribution of ethyl methanesulfonate vapors to the yield of mutations detected in Drosophila melanogaster when the adult feeding technique is used
Journal Article
·
Wed Dec 31 23:00:00 EST 1986
· Environ. Mutagen.; (United States)
·
OSTI ID:5237970
Method for selecting exposure levels for the Drosophila sex-linked recessive lethal assay
Journal Article
·
Wed Dec 31 23:00:00 EST 1986
· Environ. Mol. Mutagen.; (United States)
·
OSTI ID:5605946
Related Subjects
560304* -- Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARTHROPODS
CARBOHYDRATES
DIPTERA
DISACCHARIDES
DOSE-RESPONSE RELATIONSHIPS
DROSOPHILA
EMS
ESTERS
FLIES
FRUIT FLIES
INGESTION
INSECTS
INTAKE
INVERTEBRATES
LABELLED COMPOUNDS
LETHAL MUTATIONS
MALES
MUTAGENS
MUTATION FREQUENCY
MUTATIONS
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RECESSIVE MUTATIONS
SACCHARIDES
SACCHAROSE
SULFONIC ACID ESTERS
TOXICITY
TRITIUM COMPOUNDS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARTHROPODS
CARBOHYDRATES
DIPTERA
DISACCHARIDES
DOSE-RESPONSE RELATIONSHIPS
DROSOPHILA
EMS
ESTERS
FLIES
FRUIT FLIES
INGESTION
INSECTS
INTAKE
INVERTEBRATES
LABELLED COMPOUNDS
LETHAL MUTATIONS
MALES
MUTAGENS
MUTATION FREQUENCY
MUTATIONS
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RECESSIVE MUTATIONS
SACCHARIDES
SACCHAROSE
SULFONIC ACID ESTERS
TOXICITY
TRITIUM COMPOUNDS