Effects of prolonged daily low level mercuric chloride dosing in a horse
Relatively few of the signs hitherto accepted as being consistent with chronic inorganic mercury intoxication were exhibited by a horse exposed to 31.3 g inorganic mercury (dose rate 0.4 mg/kg) given as mercuric chloride over 23.5 weeks. Clinical features included poor appetite, weight loss, debility, dullness, transient diarrhea and polydipsia, with little impairment of functional renal capacity. Limited degenerative changes were seen in the renal tubules. Edema and a mild inflammatory infiltrate of predominantly the mucosa and submucosa caused marked thickening of the lower alimentary tract. An approximate mean plasma inorganic mercury concentration of 400 ng/ml was quickly reached and maintained. The kidneys had the highest tissue mercury content, almost 10 times greater than the liver and over 70 times that found in the intestinal mucosa and the dorsal root ganglia. 18 references, 6 figures.
- Research Organization:
- Univ. of Queensland, St. Lucia, Australia
- OSTI ID:
- 5774623
- Journal Information:
- Vet. Hum. Toxicol.; (United States), Vol. 20:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
MERCURY CHLORIDES
BIOLOGICAL EFFECTS
TISSUE DISTRIBUTION
BIOLOGICAL FUNCTIONS
BLOOD CHEMISTRY
BLOOD PLASMA
CHRONIC EXPOSURE
HORSES
KIDNEYS
PATHOLOGICAL CHANGES
SYMPTOMS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CHLORIDES
CHLORINE COMPOUNDS
DISTRIBUTION
FUNCTIONS
HALIDES
HALOGEN COMPOUNDS
MAMMALS
MATERIALS
MERCURY COMPOUNDS
MERCURY HALIDES
ORGANS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)