Effects of photoradiation therapy on normal rat brain

Journal Article · Sat Dec 01 04:00:00 EST 1984 · Neurosurgery; (United States)

DOI:https://doi.org/10.1227/00006123-198412000-00006· OSTI ID:5774247

Cheng, M K; McKean, J; Boisvert, D; Tulip, J; Mielke, B W

Laser photoradiation of the brain via an optical fiber positioned 5 mm above a burr hole was performed after the injection of hematoporphyrin derivative (HpD) in 33 normal rats and 6 rats with an intracerebral glioma. Normal rats received HpD, 5 or 10 mg/kg of body weight, followed by laser exposure at various doses or were exposed to a fixed laser dose after the administration of HpD, 2.5 to 20 mg/kg. One control group received neither HpD nor laser energy, and another was exposed to laser energy only. The 6 rats bearing an intracranial 9L glioma were treated with HpD, 5 mg/kg, followed by laser exposure at various high doses. The temperature in the cortex or tumor was measured with a probe during laser exposure. The rats were killed 72 hours after photoradiation, and the extent of necrosis of cerebral tissue was measured microscopically. In the normal rats, the extent of brain damage correlated with increases in the dose of both the laser and the HpD. In all 6 glioma-bearing rats, the high laser doses produced some focal necrosis in the tumors but also damaged adjacent normal brain tissue. The authors conclude that damage to normal brain tissue may be a significant complication of high dose photoradiation therapy for intracranial tumors.

• Research Organization: Univ. of Alberta, Edmonton, Canada
• OSTI ID: 5774247
• Journal Information: Neurosurgery; (United States), Journal Name: Neurosurgery; (United States) Vol. 15:6; ISSN NRSRD
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
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GLIOMAS
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HETEROCYCLIC ACIDS
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NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PIGMENTS
PORPHYRINS
RADIATION DOSES
RADIATION EFFECTS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RATS
RODENTS
SIDE EFFECTS
SYNERGISM
THERAPY
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