Comparative gastrointestinal blood loss associated with placebo, aspirin, and nabumetone as assessed by radiochromium (/sup 51/Cr)

Journal Article · Wed Mar 01 00:00:00 EST 1989 · J. Clin. Pharmacol.; (United States)

DOI:https://doi.org/10.1002/j.1552-4604.1989.tb03317.x· OSTI ID:5767732

Lussier, A; Davis, A; Lussier, Y; Lebel, E

Nabumetone differs from most other nonsteroidal anti-inflammatory drugs. It is presented to the gut as a nonacidic prodrug, and is metabolized to its active form after absorption. Studies in animals and humans suggest it is less irritating to the gastrointestinal mucosa. This study compared the gastrointestinal microbleeding induced by nabumetone to aspirin (acetylsalicylic acid, ASA), and placebo in a double blind parallel study using chromium /sup 51/Cr labelled red cells to quantitate fecal blood loss (FBL) in healthy volunteers. Thirty subjects were randomized to treatment with nabumetone (2000 mg), ASA (3.6 g) or placebo for 21 days following a 7 day placebo period. Six subjects served as untreated controls. FBL in nabumetone treated subjects was not significantly different to placebo or untreated subjects. In contrast, ASA-treated subjects exhibited significantly increased FBL than the other 3 groups (P less than .0001).

• Research Organization: Univ. of Sherbrooke, Quebec (Canada)
• OSTI ID: 5767732
• Journal Information: J. Clin. Pharmacol.; (United States), Vol. 29:3
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ACETYLSALICYLIC ACID
BIOLOGICAL EFFECTS
ANTIPYRETICS
DIGESTIVE SYSTEM DISEASES
PATHOGENESIS
GASTROINTESTINAL TRACT
CHROMIUM 51
COMPARATIVE EVALUATIONS
ERYTHROCYTES
HEMORRHAGE
MAN
METABOLISM
MUCOUS MEMBRANES
TRACER TECHNIQUES
ANALGESICS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHROMIUM ISOTOPES
DIGESTIVE SYSTEM
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HYDROXY ACIDS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
MEMBRANES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PRIMATES
RADIOISOTOPES
SYMPTOMS
VERTEBRATES
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