Application of radionuclide ventriculography to cardiac screening

Journal Article · Mon May 01 04:00:00 EDT 1989 · Clin. Cardiol.; (United States)

DOI:https://doi.org/10.1002/clc.4960120507· OSTI ID:5767095

Lindsay, J Jr; Milner, M R; Chandeysson, P L; Rodman, D J; Okin, P M; Goldstein, S A

Screening asymptomatic individuals for latent coronary disease often requires sequential testing because exercise electrocardiography typically produces more false positive than true positive results in a population with a low prevalence of coronary disease. Cardiac scintigraphy is a technique that may be employed as a confirmatory test in lieu of coronary arteriography to further evaluate the significance of a positive exercise electrocardiogram. Radionuclide ventriculography was employed in 98 asymptomatic individuals who were considered to be at moderate risk of heart disease after risk factor analysis and exercise electrocardiography. Seventeen (17%) patients had an abnormal study and underwent cardiac catheterization. Seven had coronary artery disease, two had cardiomyopathy, and eight were normal. Eighty-one (83%) patients had a normal study. Because the sensitivity of radionuclide ventriculography is 63-80%, it was postulated that 2 to 5 individuals with disease were missed. Thus, from a population with an 11-14% prevalence of disease, two subsets were identified. A large subset in which a prevalence of 2-6% could be estimated was separated from a much smaller one in which a prevalence of approximately 50% was demonstrated.

• Research Organization: George Washington Univ. School of Medicine, Washington, DC (USA)
• OSTI ID: 5767095
• Journal Information: Clin. Cardiol.; (United States), Journal Name: Clin. Cardiol.; (United States) Vol. 12:5; ISSN CLCAD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSIS
DIAGRAMS
DISEASES
ELECTROCARDIOGRAMS
EXERCISE
HEART
ORGANS
PATIENTS
RADIOISOTOPE SCANNING