Attempts to produce taste-aversion learning in rats exposed to 60-Hz electric fields
A measure of taste-aversion (TA) learning was used in three experiments to 1) determine whether exposure to intense 60-Hz electric fields can produce TA learning in male Sprague-Dawley rats, and (2) establish a dose-response function for the behavior in question. In Experiment 1, four groups of eight rats each were distributed into one of two exposures (69 +/- 5 kV/m or 133 +/- 10 kV/m) or into one of two sham-exposure groups. Conditioning trials paired 0.1% sodium saccharin in water with 3 h of exposure to a 60-Hz electric field. Following five conditioning trials, a 20-min, two-bottle preference test between water and saccharin-flavored water failed to reveal TA conditioning in exposed groups. In Experiment 2, four groups of eight rats each (34 +/- 2 kV/m or 133 +/- 10 kV/m and two sham-exposed groups) were treated as before. Electric-field exposure had no effect on TA learning. Experiment 3 tested for a possible synergy between a minimal dose (for TA learning) of cyclophosphamide (6 mg/kg) and 5 h of exposure to 133 +/- 10 kV/m electric fields in a dark environment under conditions otherwise similar to those of Experiments 1 and 2. The results indicated no TA learning as reflected in the relative consumption of saccharin. 16 references, 6 figures, 1 table.
- Research Organization:
- Pacific Northwest Lab., Richland, WA
- OSTI ID:
- 5766470
- Journal Information:
- Bioelectromagnetics (N.Y.); (United States), Journal Name: Bioelectromagnetics (N.Y.); (United States) Vol. 5; ISSN BLCTD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BODY
DATA
DRUGS
ELECTRIC FIELDS
ELECTROMAGNETIC RADIATION
ENDOXAN
EXPERIMENTAL DATA
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
IMMUNOSUPPRESSIVE DRUGS
INFORMATION
LEARNING
MAMMALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
RADIATIONS
RATS
RODENTS
SACCHARIN
SENSE ORGANS
SYNERGISM
TASTE BUDS
THIAZOLES
VERTEBRATES
VISIBLE RADIATION
WATER