Effects of subacute treatment with cocaine on activities of n-demethylase, UDP-glucuronyltransferase and sulfotransferase in WKY and SHR rat liver - sex and strain differences

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(88)90626-1· OSTI ID:5764803

Watanabe, H K; Hoskins, B; Ho, I K

The effects of subacute treatment with cocaine on activities of cocaine N-demethylase, UDP-glucuronyltransferase (GT) toward 4-nitrophenol and phenolphthalein and sulfotransferase (ST) toward androsterone and 4-nitrophenol in livers from Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were investigated. Hepatic metabolism of cocaine was different between the sexes (with males having higher N-demethylase activity) and the strains (with WKY rats having higher activity). The effects of subacute cocaine administration on the activity of cocaine N-demethylase were also sex- and strain-related. Whereas cocaine administration increased activity of hepatic N-demethylase in both female strains, it decreased activity in male WKY and had no effect on activity in male SHR. Sex and strain-related as well as cocaine-induced differences were also found in activities of hepatic GT toward 4-nitrophenol and phenolphtalein as well as in activity of hepatic ST towards andersterone and 4-nitrophenol. These results suggest that some of the individual variation in the effects of cocaine may be due to sex and genetic differences in the hepatic metabolism of cocaine and/or in sexually and/or genetically-determined differences in how cocaine affects hepatic metabolism of other xenobiotics. 20 references, 4 figures.

• Research Organization: Univ. of Mississippi Medical Center, Jackson
• OSTI ID: 5764803
• Journal Information: Life Sci.; (United States), Vol. 42:1
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
COCAINE
BIOLOGICAL EFFECTS
METABOLISM
NITROPHENOL
OXIDOREDUCTASES
ENZYME ACTIVITY
TRANSFERASES
GENETIC VARIABILITY
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GLANDS
HYDROXY COMPOUNDS
MAMMALS
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ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
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PSYCHOTROPIC DRUGS
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560300* - Chemicals Metabolism & Toxicology