Assessment of cobalt 57 tagged bleomycin as a clinical aid in staging of head and neck carcinoma

Journal Article · Wed Apr 01 04:00:00 EST 1981 · Laryngoscope; (United States)

DOI:https://doi.org/10.1288/00005537-198104000-00006· OSTI ID:5764360

Cummings, C W; Larson, S M; Dobie, R A; Weymuller, Jr, E A; Rudd, T G; Merello, A

Critical assessment of head and neck cancer with respect to staging has, on occasion, been disappointingly ineffective. The incidence of measurable uptake of cobalt 57 tagged bleomycin by primary squamous cell carcinoma and metastatic cervical lymph nodes has been correlated. Forty-six cases have been evaluated with respect to histopathological confirmation of the suspected metastatic disease. We have found that this diagnostic measure increases our acumen in staging of head and neck cancer. The relevance of the Co-Bleo scans as a diagnostic aid is reported in 46 cases. Malignant tumors greater than 2 cm in size appear to demonstrate active uptake of the imaging agent. Small tumor size and excess background radioactivity contribute to the false-negatives (17%). Inflammatory conditions or benign tumors of the salivary apparatus may result in minimal uptake, thus, a false-positive result (10%). An increase in the radioactivity of the Co-Bleo may enhance the benefits of this procedure in the search for an undiagnosed primary, as well as undiagnosed local or distant metastases.

• Research Organization: Univ. of Washington, Seattle
• OSTI ID: 5764360
• Journal Information: Laryngoscope; (United States), Journal Name: Laryngoscope; (United States) Journal Issue: 4 Vol. 91:4; ISSN LARYA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560171 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BLEOMYCIN
BODY
BODY AREAS
CARCINOMAS
COBALT 57
COBALT ISOTOPES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC USES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEAD
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
METASTASES
NECK
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
PATHOLOGY
PATIENTS
RADIOISOTOPES
RADIONUCLIDE KINETICS
USES