Giant-cell interstitial pneumonia and hard-metal pneumoconiosis. A clinicopathologic study of four cases and review of the literature

Journal Article · Sat Jul 01 04:00:00 EDT 1989 · Am. J. Surg. Pathol.; (United States)

DOI:https://doi.org/10.1097/00000478-198907000-00006· OSTI ID:5764122

Ohori, N P; Sciurba, F C; Owens, G R; Hodgson, M J; Yousem, S A

We report four cases of giant-cell interstitial pneumonia that occurred in association with exposure to hard metals. All patients presented with chronic interstitial lung disease and had open-lung biopsies that revealed marked interstitial fibrosis, cellular interstitial infiltrates, and prominent intraalveolar macrophages as well as giant cells displaying cellular cannibalism. We also review the literature to determine the sensitivity and specificity of giant-cell interstitial pneumonia for hard-metal pneumoconiosis. Although hard-metal pneumoconiosis may take the form of usual interstitial pneumonia, desquamative interstitial pneumonia, and giant-cell interstitial pneumonia, the finding of giant-cell interstitial pneumonia is almost pathognomonic of hard-metal disease and should provoke an investigation of occupational exposure. 25 references.

• Research Organization: Univ. of Pittsburgh School of Medicine, PA (USA)
• OSTI ID: 5764122
• Journal Information: Am. J. Surg. Pathol.; (United States), Journal Name: Am. J. Surg. Pathol.; (United States) Vol. 13:7; ISSN AJSPD
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALLOYS
ANIMALS
BODY
DISEASES
DOCUMENT TYPES
ELEMENTS
FIBROSIS
HAZARDS
HEALTH HAZARDS
LUNGS
MAMMALS
MAN
METALLURGY
METALS
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PNEUMOCONIOSES
PRIMATES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
REVIEWS
VERTEBRATES