Complications of definitive radiotherapy for carcinoma of the prostate

Journal Article · Thu Oct 01 00:00:00 EDT 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90029-8· OSTI ID:5763460

Pilepich, M V; Perez, C A; Waltz, B J; Zivnuska, F R

Treatment morbidity associated with definitive radiotherapy is analyzed in a group of 267 patients treated between 1967 and 1978. Minimum follow-up is 2 years, median is 4 years. The majority (82%) of the patients were treated with 22 MV photon beam to a pelvic dose of approximately 5000 rad followed by a boost to gradually reduced fields to a total of 6500-7000 rad to the prostate. The most frequent complications were urethral stricture (5.2% of the patients), proctitis (4.5%), bladder injuries (3.4%) and leg edema (3.0). The incidence of radiation-induced complications did not correlate with the total dose, previous transurethral resection or patients' age. Pelvic lymphadenectomy was associated with a 25% incidence of leg and genital edema. Small bowel obstruction developed in 2 of 3 patients who had transperitoneal laparotomy prior to treatment. Symptoms secondary to bladder and rectal injuries were reverisble in over 50% of patients within the first year after the onset.

• Research Organization: Washington Univ. School of Medicine, St. Louis, MO
• OSTI ID: 5763460
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:10; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BEAMS
BLADDER
BODY
DISEASES
DOSES
GLANDS
MALE GENITALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PHOTON BEAMS
PROSTATE
RADIATION DOSES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURGERY
THERAPY
URINARY TRACT