Suppression of the mixed leukocyte response and of graft-vs-host disease by spleen cells following total lymphoid irradiation

Journal Article · Sat Feb 28 23:00:00 EST 1981 · J. Immunol.; (United States)

OSTI ID:5762223

King, D P; Srober, S; Kaplan, H S

Total lymphoid irradiation (TLI) was administered to mice as 17 fractions of 200 rads delivered to the major lymphoid organs. Spleen cells capable of suppressing the in vitro mixed leukocyte response (MLR) and in vivo graft-vs-host disease (GVHD) were found in mice after treatment with TLI. Suppression was not antigen specific and was markedly reduced by treatment of the spleen cells with anti-Thy-1.2 antiserum and complement. Suppressor activity declined with time after irradiation and disappeared within 30 to 40 days. The evidence suggests that the suppressor cells may prevent initial BM rejection and acute GVHD in allogeneic BM transplant recipients prepared with TLI.

• OSTI ID: 5762223
• Journal Information: J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 126:3; ISSN JOIMA
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
DOSES
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
GRAFT-HOST REACTION
IMMUNOSUPPRESSION
IRRADIATION
LYMPHATIC SYSTEM
MAMMALS
MICE
RADIATION DOSES
RADIATION EFFECTS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION