Scanning and transmission electron microscopy of the damage to small intestinal mucosa following X irradiation or hyperthermia
Scanning and transmission electron microscopy (S.E.M. and T.E.M.) and resin histology have been used to investigate the effects on mouse small intestinal villi of heating at 43 degrees C for 20 minutes and of irradiation with 10 Gy X-rays. Damage after irradiation included conical villi and giant cells. Damage after heating included the production of conical and rudimentary villi and the stacking of enterocytes. Individual cells showed signs of abnormalities in their cell membranes, nuclei and cytoplasmic components. The differences in the response after irradiation and hyperthermia are linked to the fact that heating has a primary effect on villous structure, whereas irradiation mainly affects the proliferative pool of crypt cells.
- Research Organization:
- Anatomy Department, University of Glasgow
- OSTI ID:
- 5762201
- Journal Information:
- Scanning Electron Microsc.; (United States), Journal Name: Scanning Electron Microsc.; (United States)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
MUCOUS MEMBRANES
BIOLOGICAL RADIATION EFFECTS
SMALL INTESTINE
HYPERTHERMIA
MICE
TEMPERATURE EFFECTS
ULTRASTRUCTURAL CHANGES
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY TEMPERATURE
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
GASTROINTESTINAL TRACT
INTESTINES
IONIZING RADIATIONS
MAMMALS
MEMBRANES
MORPHOLOGICAL CHANGES
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals