Human papillomavirus types 16 and 18 in adenocarcinoma of the uterine cervix

Journal Article · Wed May 01 00:00:00 EDT 1991 · American Journal of Clinical Pathology; (USA)

DOI:https://doi.org/10.1093/ajcp/95.5.647· OSTI ID:5761518

Leminen, A; Paavonen, J; Vesterinen, E; Wahlstroem, T R; Rantala, I; Lehtinen, M ^[1]

---

1. Helsinki Univ. Central Hospital, (Finland)

Many reports have shown a link between human papillomavirus (HPV) and cervical squamous neoplasia. However, the association of HPV with cervical adenocarcinoma has been studied less extensively. The authors evaluated the presence of HPV-DNA in 106 patients with adenocarcinoma of the uterine cervix by in situ hybridization, using {sup 35}S-labeled probes for HPV 16 DNA and HPV 18 DNA. The overall prevalence of HPV-DNA was 18% (19 of 106). HPV 16 was present in 2 (2%) cases, HPV 18 was observed in 15 (14%) cases, and both HPV 16 and HPV 18 were found in 2 (2%) cases. There was a correlation between HPV-DNA positivity and tumor stage (P less than 0.01) and tumor size (P less than 0.05), but there was no relationship between HPV-DNA positivity and tumor differentiation, proliferation (S-phase fraction), ploidy, lymph node metastases, or five-year survival rate. These results suggest that HPV 18 DNA is associated with cervical adenocarcinoma but the presence of HPV 18 has no influence on overall survival.

• OSTI ID: 5761518
• Journal Information: American Journal of Clinical Pathology; (USA), Vol. 95:5; ISSN 0002-9173
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
TUMOR CELLS
CELL PROLIFERATION
UTERUS
CARCINOMAS
VIRUSES
DNA
CELL FLOW SYSTEMS
DNA HYBRIDIZATION
MAN
PATIENTS
SULFUR 35
SURVIVAL CURVES
TRACER TECHNIQUES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
FEMALE GENITALS
HYBRIDIZATION
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MICROORGANISMS
NEOPLASMS
NUCLEI
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PARASITES
PRIMATES
RADIOISOTOPES
SULFUR ISOTOPES
VERTEBRATES
550901* - Pathology- Tracer Techniques