Assessment of jeopardized myocardium in patients with one-vessel disease

Conference · Sun Jan 31 23:00:00 EST 1982 · Circulation; (United States)

OSTI ID:5761186

Iskandrian, A S; Lichtenberg, R; Segal, B L; Mintz, G S; Mundth, E D; Hakki, A -H; Kimbiris, D; Bemis, C E; Croll, M N; Kane, S A

The size of the perfusion defect was assessed from a quantitative analysis of exercise thallium-201 images. Quantitative analysis was determined by measuring the area and the perimeter of the perfusion defect and expressing it as a percentage of the total left ventricular area or perimeter in three projections. Using this technique, we studied 50 patients with one-vessel disease of 50% or greater diameter narrowing. The planimetric and the perimetric methods correlated well (p<0.001, r=0.97). Of the 11 patients with less than 70% diameter narrowing, only one patient had abnormal exercise thallium-201 images. Of the remaining 39 patients with 70% or greater diameter narrowing, 35 had abnormal exercise images. The defects were larger in patients with left anterior descending coronary artery disease (33 +/- 10%; mean +/- SD by perimetry) than in patients with left circumflex coronary artery disease (19 +/- 14%, p<0.01) or right coronary artery disease (17 +/- 11%, p<0.01). There was also significant variation in the sizes of the defects in the three projections in patients with left circumflex and right coronary artery disease, but not in patients with left anterior descending coronary artery disease. Patients with left anterior descending coronary artery disease with collaterals had smaller defects than their counterparts without collaterals (25 +/- 6% vs 40 +/- 8%, p<0.001).

• Research Organization: Hahnemann Medical College and Hospital, Philadelphia, PA
• OSTI ID: 5761186
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 65:2; ISSN CIRCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CORONARIES
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
EXERCISE
HEART
HEAVY NUCLEI
ISOTOPES
LABELLED COMPOUNDS
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATIENTS
PERFUSED TISSUES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
THALLIUM 210
THALLIUM ISOTOPES
TISSUES