Behavioral toxicity of chronic postweaning lead exposure in the rat

Journal Article · Mon Jan 01 04:00:00 EST 1979 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(79)90082-6· OSTI ID:5760638

Cory-Slechta, D A; Thompson, T

Effects in the rat of chronic postweaning exposure to 50, 300, or 1000 ppM lead acetate in drinking water were assessed on responding maintained by a fixed-interval 30-s food reinforcement schedule. On this schedule, food reinforcement followed the first lever press response occurring at least 30 s after the preceding food delivery. Exposure to 50 and 300 ppM lead acetate increased response rates and intersubject variability, while latency, or time to initiation of responding in the interval, decreased. Exposure to 100 ppM initially decreased rates and increased latency values. Following termination of exposure to 50 ppM, response rates and latency values gradually returned to control levels. Behavioral effects produced by exposure to 50 and 300 ppM lead were similar in magnitude but varied in time to onset and decline, suggesting time-dependent, rather than concentration-dependent effects of lead.

• Research Organization: Univ. of Minnesota, Minneapolis
• OSTI ID: 5760638
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 47; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

550100* -- Behavioral Biology
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEHAVIOR
CHRONIC INTAKE
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
FEEDING
INTAKE
JUVENILES
LATENCY PERIOD
LEAD
MAMMALS
METALS
PERFORMANCE TESTING
RATS
RODENTS
TESTING
TOXICITY
VERTEBRATES