Radioimmunoassay of hair for determining opiate-abuse histories

Journal Article · Sun Jul 01 04:00:00 EDT 1979 · J. Nucl. Med.; (United States)

OSTI ID:5760223

Baumgartner, A M; Jones, P F; Baumgartner, W A; Black, C T

Heroin and morphine metabolites can be detected in hair with the use of commerically available radioimmunoassay reagents and with minor sample preparation. Hair samples obtained from morphine-treated mice and heroin users contained nanogram levels of the drug per milligram of hair (single human hair). The results of the hair analyses for all subjects admitting the use of heroin were positive, whereas the results of only 30% of thin-layer chromatographic urinanalyses of these same subjects were positive. In addition, differences in drug concentration for sections of hair near the scalp and near the distal end correlated with the length of time the drug had been used. These results exemplify the potential advantages of the use of hair analysis over urine and serum analyses in terms of accessibility, sample stability, and long-term retention of information.

• Research Organization: Aerospace Corp., El Segundo, CA
• OSTI ID: 5760223
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:7; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALOIDS
ANALGESICS
ANIMALS
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD SERUM
BODY
BODY FLUIDS
CRIME DETECTION
DRUGS
HAIR
HEROIN
ISOTOPE APPLICATIONS
MAMMALS
MAN
MICE
MORPHINE
NARCOTICS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RADIOASSAY
RADIOIMMUNOASSAY
RODENTS
SKIN
TRACER TECHNIQUES
URINE
VERTEBRATES
WASTES