In vitro assessment of the immunosuppressive effect of fractionated total lymphoid irradiation in renal allotransplantation

Journal Article · Tue Sep 01 04:00:00 EDT 1981 · Transplant. Soc., Int. Cong., Proc.; (United States)

OSTI ID:5759351

Ferguson, R M; Sutherland, D E.R.; Kim, T; Simmons, R L; Najarian, J S

Ten uremic patients at high risk for rejection (nine patients with previous rapid rejection of a first transplant and one recipient of a two-haplotype mismatch primary graft) were treated with total lymphoid irradiation (TLI) prior to transplantation. TLI was delivered to mantle and inverted-Y fields simultaneously. Patients received either 125 or 100 rads daily for no more than 5 doses per week. Total dose ranged from 1800 to 3200 rads given over 29-67 days prior to transplantation. All patients received maintenance azathioprine and prednisone after the transplantation, but antilymphocyte globulin was not given.

• Research Organization: Univ. of Minnesota School of Medicine, Minneapolis
• OSTI ID: 5759351
• Journal Information: Transplant. Soc., Int. Cong., Proc.; (United States), Journal Name: Transplant. Soc., Int. Cong., Proc.; (United States) Vol. 13:3; ISSN TICPB
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DATA
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
IMMUNOSUPPRESSION
IN VITRO
INFORMATION
INHIBITION
IRRADIATION
KIDNEYS
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MATERIALS
NUMERICAL DATA
ORGANS
PATIENTS
SOMATIC CELLS
TRANSPLANTS