Comparison of survival rates for patients with uveal melanoma after treatment with proton beam irradiation or enucleation

Journal Article · Fri Mar 15 04:00:00 EST 1985 · Am. J. Ophthalmol.; (United States)

DOI:https://doi.org/10.1016/0002-9394(85)90357-5· OSTI ID:5750548

Seddon, J M; Gragoudas, E S; Albert, D M; Hsieh, C C; Polivogianis, L; Friedenberg, G R

A comparison was made of survival experiences for three groups with uveal melanoma: (1) 120 patients treated by proton beam irradiation from 1975 to 1981; (2) 235 patients treated by enucleation from 1953 to 1973 (enucleation group 1); and (3) 161 patients treated by enucleation from 1975 to 1981 (enucleation group 2). The following variables were predictive of melanoma-related deaths. Treatment: rate ratio (ratio of the rate of death for one category of the variable relative to the rate of death for another category) of 6.32 (95% confidence interval 1.70 to 23.51) for enucleation group 1 vs proton beam, 3.06 (0.81 to 11.54) for enucleation group 2 vs proton beam, and 2.07 (1.05 to 4.07) for enucleation group 1 vs enucleation group 2. Size: rate ratio of 3.61 (1.51 to 8.64) for large (16+ mm) vs small (less than 11 mm) tumors. Location: rate ratio of 3.19 (1.56 to 6.53) for tumors anterior vs posterior to the equator. When death from all causes was evaluated as the outcome, the estimated rate ratios were similar. When melanoma metastasis was evaluated as the outcome, the estimated rate ratios were reduced in magnitude.

• Research Organization: Harvard Medical School, MA
• OSTI ID: 5750548
• Journal Information: Am. J. Ophthalmol.; (United States), Journal Name: Am. J. Ophthalmol.; (United States) Vol. 99:3; ISSN AJOPA
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BEAMS
BODY
BODY AREAS
DISEASES
EVALUATION
EYES
FACE
HEAD
MEDICINE
MELANOMAS
METASTASES
MORTALITY
NEOPLASMS
NUCLEAR MEDICINE
NUCLEON BEAMS
ORGANS
PARTICLE BEAMS
PATIENTS
PROTON BEAMS
RADIOLOGY
RADIOTHERAPY
SENSE ORGANS
SURGERY
SURVIVAL CURVES
THERAPY