Evaluation of the vesicating properties of neutralized chemical agent identification sets. Final report, November 1995-August 1997
Vesication and skin irritation studies were conducted in hairless guinea-pigs to determine the vesicant and skin irritation potential of Chemical Agent Identification Sets (CAIS). Guinea-pigs were topically dosed with `test article` NEAT HD, 10% agent/chloroform solutions, or product solutions (wastestreams) and evaluated for skin-damaging effects (gross and light microscopic). Product solutions from the chemical neutralization of neat sulfur mustard resulted in microvesicle formation (vesication). All agent-dosed (agent/chloroform solutions or HD) sites exhibited microblisters, as well as other histopathologic lesions of the skin. Wastestreams from the neutalization of agent (agent/chloroform; agent on charcoal) were devoid of microvesicant activity. Dermal irritant effects (erythema and edema) were consistent with the skin-injurious activity associated with the neutralizing reagent 1,3-dichloro-5,5-dimethylhydantoin (DCDMH).
- Research Organization:
- Edgewood Research, Development and Engineering Center, Aberdeen Proving Ground, MD (United States)
- OSTI ID:
- 574931
- Report Number(s):
- AD-A--332661/8/XAB; ERDEC-SP--054
- Country of Publication:
- United States
- Language:
- English
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