Effect of single-dose radiation on cell survival and growth hormone secretion by rat anterior pituitary cells
Journal Article
·
· Radiat. Res.; (United States)
Cranial irradiation has been shown to impair growth hormone secretion in children. In this study a cell culture of dispersed rat anterior pituitary cells was exposed to single doses of radiation in the range of 100 to 1500 rad. Survival curves were obtained for the different anterior pituitary cell lines, and growth hormone secretion was measured in the tissue culture medium. Both survival and growth hormone secretion curves showed an initial shoulder in the range of 0 to 300 rad, followed by a decline between 300 to 750 rad. It is concluded that growth hormone secreting acidophilic pituicytes are sensitive to radiation at single doses greater than 300 rad.
- Research Organization:
- Technion-Israel Inst. of Tech., Haifa, Israel
- OSTI ID:
- 5742722
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 94:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
GLANDS
HORMONES
IN VITRO
INHIBITION
IONIZING RADIATIONS
MAMMALS
ORGANS
PEPTIDE HORMONES
PITUITARY GLAND
PITUITARY HORMONES
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
STH
SURVIVAL CURVES
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
GLANDS
HORMONES
IN VITRO
INHIBITION
IONIZING RADIATIONS
MAMMALS
ORGANS
PEPTIDE HORMONES
PITUITARY GLAND
PITUITARY HORMONES
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
STH
SURVIVAL CURVES
VERTEBRATES
X RADIATION