Piperazine-induced airway symptoms: exposure-response relationships and selection in an occupational setting
Journal Article
·
· Am. J. Ind. Med.; (United States)
The heterocyclic secondary amine piperazine is known to cause asthma. In a cohort of 602 workers, employed during the period 1942-1979, at a chemical industry where piperazine is handled, a study conducted by means of a mailed questionnaire showed a strong exposure-response relationship as to frequency of work-related airway symptoms indicating asthma. In the most exposed group about a third of the workers had experienced such symptoms. Age, length of employment, smoking habits, and previous work-related asthmatic symptoms, but not atopy, modified the response. Further, there was an association between piperazine exposure and chronic bronchitis. In the most exposed group every fourth subject had chronic bronchitis. The frequency was modified by smoking habits; atopy was a confounder. Although many subjects, especially high-exposed ones, left work because of airway symptoms, there was no difference in occurrence of airway symptoms between former and present employees.
- Research Organization:
- Univ. Hospital, Lund, Sweden
- OSTI ID:
- 5741630
- Journal Information:
- Am. J. Ind. Med.; (United States), Journal Name: Am. J. Ind. Med.; (United States) Vol. 6:5; ISSN AJIMD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ASTHMA
AZINES
BRONCHITIS
COLLOIDS
DISEASES
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
HAZARDS
HEALTH HAZARDS
HETEROCYCLIC COMPOUNDS
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PERSONNEL
PIPERAZINES
PYRAZINES
RESIDUES
RESPIRATORY SYSTEM DISEASES
SENSITIVITY
SMOKES
SOLS
SYMPTOMS
TOBACCO SMOKES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ASTHMA
AZINES
BRONCHITIS
COLLOIDS
DISEASES
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
HAZARDS
HEALTH HAZARDS
HETEROCYCLIC COMPOUNDS
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PERSONNEL
PIPERAZINES
PYRAZINES
RESIDUES
RESPIRATORY SYSTEM DISEASES
SENSITIVITY
SMOKES
SOLS
SYMPTOMS
TOBACCO SMOKES