Response of cerebral blood flow to changes in carbon dioxide tension during hypothermic cardiopulmonary bypass

Journal Article · Thu May 01 04:00:00 EDT 1986 · Anesthesiology; (United States)

DOI:https://doi.org/10.1097/00000542-198605000-00006· OSTI ID:5739357

Prough, D S; Stump, D A; Roy, R C; Gravlee, G P; Williams, T; Mills, S A; Hinshelwood, L; Howard, G

Changes in cerebral blood flow (CBF) in response to changes in PaCO/sub 2/ were measured by intraaortic injection of /sup 133/Xe in 12 patients during hypothermic (23-30 degrees C) cardiopulmonary bypass. In each patient, CBF was determined at two randomly ordered levels of PaCO/sub 2/ obtained by varying the rate of gas inflow into the pump oxygenator (Group I, n = 6) or by varying the percentage of CO/sub 2/ added to the gas inflow (Group II, n = 6). Nasopharyngeal temperature, mean arterial pressure, pump-oxygenator flow, and hematocrit were maintained within a narrow range. In group I, a PaCO/sub 2/ (uncorrected for body temperature) of 36 +/- 4 mmHg (mean +/- SD) was associated with a CBF of 13 +/- 5 ml X 100 g-1 X min-1, while a PaCO/sub 2/ of 42 +/- 4 mmHg was associated with a CBF of 19 +/- 10 ml X 100 g-1 X min-1. In group II, a PaCO/sub 2/ of 47 +/- 3 mmHg was associated with a CBF of 20 +/- 8 ml X 100 g-1 X min-1, and a PaCO/sub 2/ of 53 +/- 3 mmHg was associated with a CBF of 26 +/- 9 ml X 100 g-1 X min-1. Within group I, the difference in CBF was significant (P less than 0.05); within group II, the difference in CBF was significant at the P less than 0.002 level. All CBF measurements were lower than those reported for normothermic, unanesthetized subjects of similar age.

• Research Organization: Wake Forest Univ. Medical Center, Winstn-Salem, NC
• OSTI ID: 5739357
• Journal Information: Anesthesiology; (United States), Journal Name: Anesthesiology; (United States) Vol. 5; ISSN ANESA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANESTHESIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD PRESSURE
BODY
BRAIN
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
HEART
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
NERVOUS SYSTEM
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PARTIAL PRESSURE
PATIENTS
RADIOISOTOPES
SURGERY
XENON 133
XENON ISOTOPES