Non-cancer dose-response assessments within the EPA (Environmental Protection Agency): A foundation for selecting a dose-response assessment method to assess Section 112 pollutants based on non-cancer effects. Technical report
Technical Report
·
OSTI ID:5738898
Regulations concerning hazardous pollutants within the EPA's Office of Air and Radiation have historically focused on chronic continuous exposure, with cancer as the chief health endpoint of concern. Exposures to these hazardous substances are averaged over an annual period, allowing for exposure levels to fluctuate over short periods of time (e.g. episodic releases of a plume through a pressure relief valve would contribute to such fluctuations). There is concern that significant non-cancer risks may result from these episodic exposures. This report provides a foundation for a decision of how risks from non-cancer effects should be assessed in developing regulations under the NESHAP program. This foundation is built by focusing on trends in current non-cancer risk assessment practices across program offices within the Agency, and, to the extent such information is available, the conditions which have driven these trends. The report focuses on the dose response evaluation, a step in the risk assessment process. The sources of information for the study include reports and various other EPA documents, as well as interviews of personnel in the EPA Office of Water, Office of Solid Waste, Office of Drinking Water, Office of Toxic Substances, Office of Air and Radiation, and the Office of Pesticide Programs.
- Research Organization:
- Colorado Univ., Boulder, CO (USA)
- OSTI ID:
- 5738898
- Report Number(s):
- PB-89-203657/XAB
- Country of Publication:
- United States
- Language:
- English
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DRINKING WATER
ELEMENTS
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