Graft-versus-host reaction in small bowel transplantation and possibilities for its circumvention

Journal Article · Sat Mar 01 04:00:00 EST 1986 · Am. J. Surg.; (United States)

DOI:https://doi.org/10.1016/0002-9610(86)90473-3· OSTI ID:5737859

Deltz, E; Ulrichs, K; Schack, T; Friedrichs, B; Mueller-Ruchholtz, W M; Mueller-Hermelink, H K.T.; Thiede, A

To describe GVHR in small bowel transplantation and its underlying mechanisms and to find methods for circumventing that response, accessory small bowel transplantation was carried out in the rat model. Animals not treated with cyclosporine, irradiation, or removal of the mesenteric lymph nodes of the graft died within 22 days postoperatively due to graft versus host disease. Mesenteric lymph nodes of the graft and recipient spleen and peripheral lymph nodes showed strong immunologic stimulation histologically and high antihost T-cell-mediated cytotoxic antihost reactivity. Seventy-one percent of the animals that had received 15 mg of cyclosporine per kilogram body weight orally survived 150 days after transplantation. After donor irradiation with 50 rads, 77 percent of the recipients survived 120 days. After microsurgical removal of the mesenteric lymph nodes of the graft, 89 percent survived 120 days. We conclude that GVHR plays an important role in small bowel transplantation and that the experimental regimens of donor, graft, and recipient treatment described herein have proved their efficacy for circumventing GVHR.

• Research Organization: Univ. of Kiel, West Germany
• OSTI ID: 5737859
• Journal Information: Am. J. Surg.; (United States), Journal Name: Am. J. Surg.; (United States) Vol. 3; ISSN AJSUA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BODY
DIGESTIVE SYSTEM
EXTERNAL IRRADIATION
GASTROINTESTINAL TRACT
GRAFT-HOST REACTION
IMMUNE REACTIONS
IMMUNOSUPPRESSION
INTESTINES
IRRADIATION
LYMPH NODES
LYMPHATIC SYSTEM
MAMMALS
MEMBRANES
MESENTERY
ORGANS
RADIATION EFFECTS
RATS
RODENTS
SEROUS MEMBRANES
SMALL INTESTINE
SPLEEN
SURVIVAL TIME
TRANSPLANTS
VERTEBRATES